How To Use | Genotropin® (somatropin) For Injection | Safety Info (2022)

Growth hormone should not be used to increase height in children after the growth plates have closed.

Growth hormone should not be used in patients with diabetes who have certain types of diabetic retinopathy (eye problems).

Growth hormone should not be used in patients who have been recently diagnosed with cancer, with cancer, or who are being treated for cancer. Growth hormone deficiency can be caused by brain tumors. So, the presence of these brain tumors should be ruled out before treatment is started. Growth hormone should not be used if it is shown that a previous brain tumor has come back or is getting larger.

Growth hormone should not be used in patients who are critically ill because of surgery, trauma, or respiratory failure.

Growth hormone should not be used in children with Prader-Willi syndrome who are very overweight or have severe breathing problems.

GENOTROPIN should not be used by patients who have had an allergy or bad reaction to somatropin or any of the other ingredients in GENOTROPIN. In the event of an allergic reaction, seek prompt medical attention.

Some patients have developed diabetes mellitus while taking GENOTROPIN. Dosage of diabetes medicines may need to be adjusted during growth hormone treatment. Patients should be watched carefully if growth hormone is given along with glucocorticoid therapy and/or other drugs that are processed by the body in the same way.

In childhood cancer survivors, treatment with growth hormone may increase the risk of a new tumor, particularly certain benign brain tumors. This risk may be higher in patients who were treated with cranial radiation. Also, patients and their doctors should check regularly for skin changes.

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A small number of patients treated with growth hormone have had increased pressure in the brain. This can cause headaches and problems with vision. Treatment should be stopped and reassessed in these patients. Patients with Turner syndrome and Prader-Willi syndrome may be at higher risk of developing increased pressure in the brain.

Thyroid function should be checked regularly during growth hormone therapy. Thyroid hormone replacement therapy should be started or adjusted if needed.

Patients treated with growth hormone should be checked regularly for low serum cortisol levels and/or the need to increase the dose of the glucocorticoids they are taking.

In children experiencing rapid growth, curvature of the spine may develop or worsen. This is also called scoliosis. Patients with scoliosis should be checked regularly to make sure their scoliosis does not get worse during their growth hormone therapy.

In children experiencing rapid growth, limping or hip or knee pain may occur. If a child getting growth hormone therapy starts to limp or gets hip or knee pain, the child’s doctor should be notified and the child should be examined.

Growth hormone should only be used during pregnancy if clearly needed. It should be used with caution in nursing mothers because it is not known whether growth hormone is passed into human milk.

Use a different place on the body each day for growth hormone injections. This can help to prevent skin problems such as lumpiness or soreness.

Some cases of pancreatitis (inflamed pancreas) have been reported rarely in children and adults receiving growth hormone. There is some evidence that there is a greater risk of this in children than in adults. Literature suggests that girls who have Turner syndrome may have a greater risk of pancreatitis than other children taking growth hormone. In any child who develops lasting, severe abdominal pain, pancreatitis should be considered.

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In studies of GENOTROPIN in children with GHD, side effects included injection site reactions, such as pain, redness/swelling, inflammation, bleeding, scarring, lumps, or rash. Other side effects were fat loss, headache, blood in the urine, low thyroid activity, and mildly increased blood sugar.

In studies of GENOTROPIN in children born SGA, side effects included temporarily elevated blood sugar, increased pressure in the brain, early puberty, abnormal jaw growth, injection site reactions, growth of moles, and worsening of scoliosis (curvature of the spine).

Deaths have been reported with the use of growth hormone in children with Prader-Willi syndrome. These children were extremely overweight, had breathing problems, and/or lung infection. All patients with Prader-Willi syndrome should be examined for these problems. They should also establish healthy weight control.

In studies of GENOTROPIN in children with PWS, side effects included fluid retention, aggressiveness, joint and muscle pain, hair loss, headache, and increased pressure in the brain.

Turner syndrome patients taking growth hormone therapy may be more likely to get ear infections. This is also called otitis media.

In studies of GENOTROPIN in children with Turner syndrome, side effects included flu, throat, ear, or sinus infection, runny nose, joint pain, and urinary tract infection.

In studies of GENOTROPIN in children with ISS, side effects included respiratory illnesses, flu, throat infection, inflammation of the nose and throat, stomach pain, headaches, increased appetite, fever, fracture, mood changes, and joint pain.

Women who are taking estrogen by mouth may take GENOTROPIN. They may need a larger dose of growth hormone.

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GENOTROPIN may be taken by the elderly when appropriate. Elderly patients may be more likely to have side effects with growth hormone therapy.

In studies of GENOTROPIN in adults with GHD, side effects included fluid retention, joint or muscle pain, stiffness, and changes in sensation. Usually these side effects did not last long and depended on the dose of GENOTROPIN being taken.

GENOTROPIN cartridges contain m-Cresol and should not be used by patients allergic to it.

A health care provider will help you with the first injection. He or she will also train you on how to inject GENOTROPIN.

Rx only

INDICATIONS

GENOTROPIN is a prescription product for the treatment of growth failure in children:

  • Who do not make enough growth hormone on their own. This condition is called growth hormone deficiency (GHD)
  • With a genetic condition called Prader-Willi syndrome (PWS). Growth hormone is not right for all children with PWS. Check with your doctor
  • Who were born smaller than most other babies born after the same number of weeks of pregnancy. Some of these babies may not show catch-up growth by age 2 years. This condition is called small for gestational age (SGA)
  • With a genetic condition called Turner syndrome (TS)
  • With idiopathic short stature (ISS), which means that they are shorter than 98.8% of other children of the same age and sex; they are growing at a rate that is not likely to allow them to reach normal adult height and their growth plates have not closed. Other causes of short height should be ruled out. ISS has no known cause

GENOTROPIN is a prescription product for the replacement of growth hormone in adults with growth hormone deficiency (GHD) that started either in childhood or as an adult. Your doctor should do tests to be sure you have GHD, as appropriate.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/MedWatch or call1-800-FDA-1088.

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How To Use | Genotropin® (somatropin) For Injection | Safety Info (1)

How To Use | Genotropin® (somatropin) For Injection | Safety Info (2)

This site is intended only for U.S. residents. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider.

How To Use | Genotropin® (somatropin) For Injection | Safety Info (3)

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FAQs

How do you give a somatropin injection? ›

The usual dose is 0.06 mg per kg of body weight, given 3 times per week and injected under the skin or into a muscle. Your doctor may adjust your dose if needed.

How long does somatropin last? ›

Protect from light. Following reconstitution, may store under refrigeration for up to 28 days. Miniquick: Store at 2°C to 8°C (36°F to 46°F) prior to dispensing; may be stored ≤25°C (77°F) for up to 3 months after dispensing.

When should I take somatropin? ›

Time of Day
  • Give GH at night, preferably within an hour of sleep. ...
  • You may change the time occasionally, by a few hours earlier or later, but do not give before 5 p.m, except under unusual circumstances (such as leaving for a trip, a sleep-over, etc.)
  • Do not make up missed injections.

How do you inject a GENOTROPIN injection? ›

Pinch a fold of skin at the injection site firmly, and push the GENOTROPIN PEN 5 into the skinfold at a 90° angle. Push the pen down as far as possible. Push the black/white injection knob until it clicks. Wait at least 5 seconds and then withdraw the GENOTROPIN PEN 5.

How much somatropin should I inject? ›

The usual total weekly dose is 0.3 milligram (mg) per kilogram (kg) (0.136 mg per pound) of body weight. This is divided into smaller doses and usually is injected under the skin, but may be injected into a muscle as determined by your doctor.

What is the use of somatropin injection? ›

Somatropin injection is used to replace growth hormone (a natural hormone produced by your body) in adults and children with growth hormone deficiency. Somatropin injection is also used to increase growth in children with certain conditions that affect normal growth and development.

Does somatropin have to be refrigerated? ›

After first injection, the Saizen cartridge or the easypod auto-injector containing the Saizen cartridge has to be stored in a refrigerator (2°C-8°C) for a maximum of 28 days, of which up to 7 days can be outside of a refrigerator at or below 25°C.

What happens if you inject too much hGH? ›

High levels of human growth hormone over a long period can produce irreversible acromegaly, but even smaller doses can lead to complications such as heart disease and diabetes. And because these hormones must be taken as injections, there are further administration risks such as a blood clot or dose error.

What happens when you stop taking hGH injections? ›

Psychological symptoms of GH withdrawal, reported in interviews at end-point by placebo-treated patients, included decreased energy, and increased tiredness, pain, irritability and depression.

How good is somatropin? ›

Somatropin has an average rating of 8.0 out of 10 from a total of 8 ratings for the treatment of Adult Human Growth Hormone Deficiency. 63% of reviewers reported a positive experience, while 0% reported a negative experience.

Is somatropin safe? ›

In some cases, somatropin should not be used in a child. Certain brands of somatropin contain an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not give this medicine to a child without medical advice. Tell your doctor if you are pregnant or breastfeeding.

How do you take somatropin 4 IU? ›

Usual Adult Dose for Adult Human Growth Hormone Deficiency

Initial dose: Not more than 0.004 mg/kg subcutaneously once a day (or a total of 0.04 mg/kg per week in divided doses). Comments: The weekly dose should be divided over 6 or 7 days of subcutaneous injections.

What size needles for HGH injection? ›

The most common size of needle used to inject anabolic steroids is a 22-23 gauge X 1.5″ needle. This size will work for all water-based and oil-based injectable steroids. The first thing you need to do is make sure you are using a clean, unused needle.

Can you inject HGH intramuscular? ›

In the treatment of growth hormone deficiency, human growth hormone (hGH) injections are given intramuscularly (IM) since subcutaneous (SC) injections are considered to be immunogenic.

How do bodybuilders use HGH? ›

HGH-deficient adults usually take 1-2 IU/d by subcutaneous injection every evening. Athletes sometimes take as much as 10-25 IU/d, three or four times a week. It is often taken in 4-6 week cycles and in combination with other performance-enhancing agents, especially anabolic steroids.

How much growth hormone should I take a day? ›

To minimize the rate of side-effects, a retrospective analysis of 28 studies of GH replacement therapy in adults indicates that the maintenance dose should usually not exceed 1.0 IU/m2/day (about 1.5-2.0 IU/day) in GHD patients 40-60 years old, or 1.5 IU/m2/day (about 2.5-3.0 IU/day) in GHD patients 20-40 years old.

How many IU of HGH do you need for a cycle? ›

HGH Cycles

When used for performance enhancement purposes, 2-4 IU per day are taken, with a maximum dosage of 6 IU used by elite bodybuilders to promote further mass gain. HGH cycles usually last anywhere from 6-24 weeks, with 16 weeks being the average duration for a standard bodybuilding cycle.

How many IU of HGH do bodybuilders take? ›

HGH Dosages For Bodybuilding

Depending on your targets, you can go for one of two options: 4-8 IU for body recomposition, general fat loss, and muscle improvement; Up to 15 IU for extreme muscle growth and strength gains.

What is the action of somatropin? ›

Somatotropin induces growth in nearly every tissue and organ in the body. It stimulates linear growth and cartilaginous growth of long bones. In children with short stature, growth hormone increases both the number and size of muscle cells.

What is another name for somatropin? ›

BRAND NAME(S): Genotropin, Humatrope, Norditropin, Nutropin, Serostim, Zorbtive.

Can adults take somatropin? ›

The beneficial effects of somatropin (growth hormone [GH] replacement therapy) in adults are now established. Long-term somatropin administration in GH-deficient adults improves body composition, muscle strength, quality of life, bone mass and density, and lipoprotein pattern.

How long does growth hormone last in the fridge? ›

You can store it in a refrigerator for up to 28 days after it has been mixed.

How long can you keep HGH out of the fridge? ›

Room temperature storage after first use. a

Most other growth hormones must be refrigerated at all times, but not Norditropin FlexPro® pens. Store them in the refrigerator at first, but after the first time you use FlexPro®, they can be kept at room temperature (up to 77°F) if you'll be using them within 21 days.

How long does a vial of HGH last? ›

Prior to reconstitution (mixing) of your growth hormone, a vial can be left out for 72 hours and then reconstituted with full effectiveness. Once a vial is reconstituted it could be left out inadvertently at normal temperatures up to 24 hours.

Which hGH is best for muscle growth? ›

HyperGH 14X is the greatest HGH supplement for guys who wish to gain muscle, lose body fat, and experience quicker exercise recovery. HyperGH 14X is a popular option among bodybuilders, athletes, and gym users for these reasons.

Does hGH make you bigger? ›

Can hGH make you taller? Human growth hormone increases vertical growth in children. However, once your growth plates have fused, hGH cannot make you taller. Instead, after you've reached your final height, hGH helps maintain your body's structure and has other important effects on your metabolism.

Can you overdose somatropin? ›

Furthermore, overdose with somatropin is likely to cause fluid retention. Long-term overdosage could result in signs and symptoms of gigantism and/or acromegaly consistent with the known effects of excess growth hormone [see Dosage and Administration (2)].

At what age do growth hormones stop working? ›

Growth hormone and IGF-1 levels peak during puberty, then gradually decline after the age of 30, but the normal pituitary never totally stops its production of hGH. Some investigators feel that diminished levels of hGH may not be a bad thing.

How quickly does HGH work? ›

Expected Results with Six Months of HGH Peptide Therapy

While patients will notice some significant increases changes in the body after the first month, the full-benefits are usually fully noticed after three to six months of therapy.

How long does it take to build muscle with HGH? ›

People who use it can expect to gain 30 to 40 pounds of muscle in 10 weeks”.

How does growth hormone work? ›

Growth hormone tells the body to grow.

When growth hormone is released from the pituitary gland, it “tells” the liver to release a second hormone, called insulin-like growth factor-1 (IGF-1). Together, growth hormone and IGF-1tell the bones, muscles, and other organs and tissues to grow by adding more cells.

Is there a generic for somatropin? ›

Genotropin (somatropin) is a growth hormone used to help children grow taller and help adults and children grow muscle. Genotropin is slightly more popular than other recombinant human growth hormones. There are currently no generic alternatives to Genotropin.

Why do men take HGH? ›

For adults who have a growth hormone deficiency, injections of HGH can: Increase exercise capacity. Increase bone density. Increase muscle mass.

Who should not take somatropin? ›

Somatropin is contraindicated in patients with Prader-Willi syndrome who are severely obese, have a history of upper airway obstruction or sleep apnea, or have severe respiratory impairment. There have been reports of sudden death when somatropin was used in such patients [see Warnings and Precautions (5.2)].

What class is somatropin? ›

Genotropin belongs to a class of drugs called Growth Hormone Analogs.

Where is somatropin made? ›

Descriptions. Somatropin is a man-made version of the human growth hormone. Growth hormone is naturally produced by the pituitary gland and is necessary to stimulate growth in children.

How do you measure IU on a syringe? ›

The Syringe is the plastic chamber that holds the medicine. It is marked with lines (calibrations) on the side. The lines show you how many units (IU) you are injecting. The plunger is the long thin rod that slides up and down the inside of the syringe.

Where can I inject growth hormone? ›

Conclusion: Subcutaneously injected GH is better absorbed from the abdominal site than from the thigh.

What is 0.5 on a syringe? ›

Read a syringe marked in consecutive increments.

For instance, your syringe may be marked with a number at every successive mL. In between you'll see a mid-sized line that marks half mL units, like 0.5 milliliters (0.02 fl oz), 1.5 mL, 2.5 mL, and so on.

Can you take HGH in the morning? ›

It is best to avoid taking higher amounts of HGH or Testosterone. To get better results, start with the lowest possible dose. I can take my doses at any time of day, whether I am full or empty stomach.

Where do I pin HGH? ›

INJECTION SITES

HGH should always be injected subcutaneously, i.e., just below the skin and into the fatty tissue. The best sites are the stomach, deltoid, and thigh. Simply pinch along the skin and inject the hormone into the roll of fat. Alternate the sites to avoid bruising.

Does somatropin increase height? ›

SOMATROPIN (soe ma TROE pin) is a man-made growth hormone. Growth hormone helps children grow taller and helps adults and children grow muscle. It is used to treat many conditions of low growth hormone levels, growth failure, and short stature.

Does HGH increase testosterone? ›

Weighing the Benefits and Risks of HGH Treatment

First, it's important to point out that HGH has very little—if any—impact on testosterone levels, as this particular protein is not involved in the production of testosterone. In the most literal sense, HGH is not an effective treatment for low testosterone.

How long does it take for somatropin to work? ›

Usually you see the greatest results within the first year, but it might also take at least 6 months before you see an increase in growth rate. Also, there tends to be greater catch-up growth with patients who start at a younger age. However, individual results may vary, so you should check with your doctor.

How do you take somatropin 4 IU? ›

Usual Adult Dose for Adult Human Growth Hormone Deficiency

Initial dose: Not more than 0.004 mg/kg subcutaneously once a day (or a total of 0.04 mg/kg per week in divided doses). Comments: The weekly dose should be divided over 6 or 7 days of subcutaneous injections.

Can you inject hGH intramuscular? ›

In the treatment of growth hormone deficiency, human growth hormone (hGH) injections are given intramuscularly (IM) since subcutaneous (SC) injections are considered to be immunogenic.

Does somatropin build muscle? ›

The balance of evidence suggests that, in healthy adults, growth hormone does not build muscle and provides no athletic advantage. Growth hormone abuse, however, does cause disease.

What is the best place to inject HGH? ›

HGH should be injected subcutaneously. This means that it should be injected just below the skin and into the fat tissue. The stomach, deltoid and thigh are the best places to inject HGH. Simply rub the hormone into the fat roll by pinching along the skin.

What are the benefits of somatropin? ›

For adults who have a growth hormone deficiency, injections of HGH can:
  • Increase exercise capacity.
  • Increase bone density.
  • Increase muscle mass.
  • Decrease body fat.

What happens if you inject too much HGH? ›

High levels of human growth hormone over a long period can produce irreversible acromegaly, but even smaller doses can lead to complications such as heart disease and diabetes. And because these hormones must be taken as injections, there are further administration risks such as a blood clot or dose error.

How many units of HGH should I inject? ›

GH treatment should be started at a low dose, i.e. about 1.0 IU/day, and increased gradually, by about 0.5 IU per month, until the target dose is reached. In the absence of side-effects, the GH dose may be either too low, adequate, or too high.

Do I need to keep HGH in fridge? ›

Store them in the refrigerator at first, but after the first time you use FlexPro®, they can be kept at room temperature (up to 77°F) if you'll be using them within 21 days. (If you need to keep a pen for up to 4 weeks, store it in the fridge.a)

What needle is best for HGH? ›

The most common size of needle used to inject anabolic steroids is a 22-23 gauge X 1.5″ needle. This size will work for all water-based and oil-based injectable steroids. The first thing you need to do is make sure you are using a clean, unused needle.

How much HGH do bodybuilders take? ›

Dosages for sport-related performance enhancement can be as low as 2IU/day, all the way up to 10IU/day taken by some professional bodybuilders. Relatively few side effects are seen at doses of <4IU/day, but doses of 8+IU/day have been known to have permanent side-effects (see acromegaly).

Can you take HGH in the morning? ›

It is best to avoid taking higher amounts of HGH or Testosterone. To get better results, start with the lowest possible dose. I can take my doses at any time of day, whether I am full or empty stomach.

What hormone increases muscle size? ›

Growth hormone is produced by our brain's pituitary gland and governs our height, bone length and muscle growth.

Does growth hormone make you bigger? ›

Can hGH make you taller? Human growth hormone increases vertical growth in children. However, once your growth plates have fused, hGH cannot make you taller. Instead, after you've reached your final height, hGH helps maintain your body's structure and has other important effects on your metabolism.

What hormone increases muscle? ›

Testosterone

This male hormone is primarily produced by the testicles (and the ovaries in women). Testosterone regulates muscle mass, strength, fat distribution, libido, and bone mass [3], making it one of the most important hormones for bodybuilding.

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