IGF-1 Lr3, Insulin Like Growth Factor 100 mcg / vial - Peptides (2022)

IGF stands for insulin-like growth factor. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body; I will only mention the points that would be important for physical enhancement. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

IGF-1 Lr3, Insulin Like Growth Factor 100 mcg / vial - Peptides (1)

When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue, IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

IGF also mimic’s insulin in the human body. It makes muscles more sensitive to insulin’s effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

(Video) 5 Functions of IGF-1 | What does IGF 1 Do?

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don’t actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter anindividual’s capacity to build superior muscle density and size. There is a lot of talk about the similarity between IGF and growth hormone. The most often asked question is simply which is more effective. GH doesn’t directly cause your muscles to grow; it works very indirectly by increasing protein synthesis capabilities, increasing the amount of insulin a person can use effectively, and increasing the amount of anabolic steroids a person can use effectively. GH also indirectly causes muscle growth by stimulating the release of IGF when it (the GH) is destroyed in the human body. So one way you could look at it as GH being a precursor to IGF. So to put it simple IGF is more effective at directly causing muscle growth and density increases. IGF is also much more cost effective.

IGF can also be effectively used by itself and gains will still be easily noticeable. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF. IGF can be used by itself and is often used by bodybuilders who bridge between cycles, during this bridge is a good time to use IGF since it has no effect on natural testosterone production so it will therefore allow you to return to normal in terms of hormone levels. A stack of IGF, PGF2a, HCG, and Clomid would be a good bridge stack and would allow your body to return to normal and still allow you to retain and make new gains. IGF is a research drug, it hasn’t been approved by the FDA for use as a pharmaceutical and it is currently being researched for nerve tissue repair, possible burn victims, and also as a possible aid in muscle wasting for AIDS patients. There are many different analogs of IGF available, instead of mentioning them all, I will simply mention the two most common and the most effective. Regular recombinant IGF is one of the two; it is also the more expensive and the least effective. Regular IGF only has a half-life of about 10-20 minutes in the human body and is quickly destroyed, it can be combined with certain binding proteins to extend the half-life, but it is not a very simple procedure and there is a more effective and less expensive version available. The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. “Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide.”

After synthesizing and screening hundreds of molecules, the researchers headed by Dr. Victor Hruby, found a peptide that after trials and testing seemed to not only be safe but also approximately 1,000 times more potent than natural α-MSH. They dubbed this new peptide Melanotan-II (MT-2). Since their discovery, numerous studies dating back to the mid-1980s have shown no obvious toxic effects of Melanotan-2. Because skin cancer (melanoma) today is a major health concern, Melanotan II (MT-2) is expected to be used as a drug to combat it. MT-2 will do this by stimulating the body’s natural tanning mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn will reduce the potential for skin damage that can eventually lead to skin cancer.

“Long R3 IGF-1 is significantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.”

It is also not as expensive since a media grade version is available which is sufficient for bodybuilding use. There is also a receptor grade available but it is VERY expensive and the only noticeable difference between the two would only be able to be noticed in a laboratory setting. The price on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per milligram depending on the source, be wary of black market dealers of any IGF since it is a VERY difficult item to obtain. As mentioned IGF is a research product and is only available from a few laboratories in the world and is only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.

Any form of IGF is ONLY supplied in a lyophilized form, which means a dry powder state. NEVER PUCHASE PRE-DILUTED LIQUID IGF!!!! There is no such product made anywhere in the world and even if there were real IGF ever present in the vial it would all be dead by the time you receive it. IGF is a very delicate peptide and must be diluted by yourself, where you have access to a refrigerator and freezer. There has also been a lot of talk by certain sources claiming to have IGF made by the Eli Lilly company, to clear things up Lilly is a pharmaceutical company and as stated IGF is a research drug and has not yet been approved, Lilly does not and never has manufactured research drugs for retail sale. The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results, and in fact several top bodybuilders use the 20mcg/day dosage and are pleased with the results. IGF is most effective when administered subcutaneously and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.

Another frequently asked question of IGF refers to the real world results, in terms of pure weight gain don’t expect to gain 5 lbs. a week like you may off of anadrol or a similar steroid. The only weight you will gain from IGF use is pure lean muscle tissue, with steroids most of the weight gained is water weight. With an effective dosage you can expect to gain 1-2 lbs. of new lean muscle tissue every 2-3 weeks and these effects can be increased with the use of testosterone, anabolic steroids, and insulin use. Increased vascularity is also very common, people report seeing veins appear where they never have before. And yet another effect reported is the ability to stay lean while bulking with heavy dosages of steroids and TONS of food while on an IGF cycle, this is perhaps the most pleasing effect. Increased pumps are also noticeable almost immediately, the pumps can almost become painful, pumps are even noticeable when doing cardio.

(Video) IGF-1 LR3 || Peptides Episode 8 || The GREATEST Performance Enhancer Of All Time?

Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities. If you can find a trustworthy source and you use it correctly it can be a VERY useful tool in your bodybuilding drug arsenal IGF1, also known as somatomedin C, is polypeptide hormone about the same size as insulin. It is produced predominantly in the liver in response to growth hormone (GH) release from the pituitary gland. Many of the growth promoting effects of GH are due to its ability to release IGF1 from the liver. The conversion ratio of GH to IGF1 varies greatly in different individuals but most external sources of GH convert around 4-6mcg of IGF per one I.U. of GH. IGF-1 acts on several different tissues to enhance growth. IGF1 belongs in the ’superfamily’ of substances known as ‘growth factors,’ along with epidermal (skin), transforming; platelet derived fibroblast, nerve, and ciliary neurotrophic growth factors. None of the other factors have any bearing on exoskeletal tissue incidentally however These agents all have in common the ability to stimulate cell division, known as mitogenesis, and cell differentiation. Meaning That In the case of IGF1 which does act on muscle tissue it will initiate the growth of new muscle fibers, and subsequently new receptors for testosterone. Users have unanimously concluded that it enhances cycles of steroids significantly. They also seem to be adamant about its ability to reduce fat and improve vascularity a great deal.

The IGF1 Hype

There is a considerable amount of hype surrounding IGF1.Everyone is blaming the distended bellies of modern Bodybuilders on it. Also the freaky proportions that old bodybuilders that have been around for years are starting to attain. Anti-aging proponents are touting it as the miracle cure for everything from Parkinson’s disease to Alzheimer’s. And the medical community has published numerous articles on it for its ability to cause cancer, diabetes and gigantism. While at the same time performing documented experiments on thousands of patients of muscle wasting diseases. And reporting significant turnabouts in there conditions. So what is a guy to think about IGF1 as far as athletic enhancement is concerned? Well first of all you need to know that most experiments conducted with IGF1 do not list the type of IGF used. I have written Dr. Robert Saline of the Swedish rejuvenation institute on several occasions and we have had in-depth discussions on the subject of IGF1 for physical appearance enhancement. He feels it would be unethical to prescribe IGF1 to a bodybuilder to increase muscle mass simply due to the fact that IGF1 has valid applications in the medical community, (Like I could give a rats ass about “ethical”). He cannot argue that it is extremely effective as a promoter of muscle growth far beyond what androgens (steroids) alone can offer. Well fortunately in America IGF1 is not a drug (yet) and the FDA has no control over it as of now. This will change in the very near future however, I’mabsolutely sure of it.

How to use IGF1

Assuming that you have acquired legitimate IGF1 (R3) long chain, that’s IGF1 with the binding protein added. You should take dosages ranging from 60mcg up to 120mcg per day in divided doses. One injection in the morning and again at bed time. Never exceed 120mcg in one day. IGF1 can cause serious gastrointestinal problems such as tumors intestinal swelling diarrhoea and vomiting. Most IGF1 comes in a concentration of 1000mcg per ML or CC so it makes it easy to measure in an insulin syringe. 10 IU on the syringe is 100mcg. Do the math.

IGF + Insulin

If you plan on doing IGF1 with Insulin, listen closely IGF1 is not that expensive, sure you can get away with using less by including insulin in the stack, but IGF1 and Insulin together have a pro-insulin effect on your blood sugar balance. It can enhance the chances of a hypoglycaemic episode tenfold. I would recommend against it for any one not ABSOLUTLY comfortable with insulin or IGF1.

Here is how insulin and IGF1 work together. Igfbp3 is the binding protein, which allows IGF1 to remain active in the system for a long enough period of time to really work its magic. IGF1 by nature has a half-life of less than 10 minutes by its self. The molecule was so small it would escape the blood stream very rapidly. This was the reason IGF1 was so “underground”. It took very frequent injections at high dosages to achieve even minimal results. Aside from this reconstituting the compound required a degree in biochemistry. This short acting version was the only IGF1 known until recently IGF1 would have been administered in 100 mcg dosages 4-6 times a day. That is a hell of a lot of IGF1. That explains a lot of the distended bellies. Now with R3 long chain IGF1 and the Binding protein IGFBP3 IGF1 will last up to 6 hours in the system. By binding IGF to the IGFBP3 you make the molecule larger and it gets trapped in the blood stream until the protein is broken down and the IGF molecule escapes. You can further its life by combining Insulin with it, although I here it’s very risky. Insulin prevents the breakdown of IGFBP3 and leaves the IGF1 molecule roaming free in the blood stream for longer periods of time up to 12 hours as insulin levels return to normal IGFBP3 will begin to break down and the IGF1 will escape from its bound protein IGFBP3 again having a half-life of less than 10 minutes.

(Video) IGF-1 (Insulin-Like Growth Factor 1) Hormone Therapy Overview & Benefits | EVOLVE Telemedicine

Insulin should be taken at the normal dosage it is usually administered at minus 10% about 45 minutes prior to the IGF1 infusion. Again let me remind you this can be deadly if you don’t know what you are doing. And of course do not use Insulin for the night-time injection of IGF1 by taking it in the morning you prolong the IGF1’s half-life to 12 hours and then take a 6 hour injection, you should be fine. Hell if you want to eat a big bowl of rice and drink another 100g of simple carbs 45 minutes before the bed time IGF1 infusion you could spike insulin for at least a few hours of extended IGF1 activity. Ifyou’re not going to be using insulin in the stack then go ahead and do the same in the morning.

What users report

Users of IGF1 have reported various results but all along the same lines, It does not appear to be dramatically less effective in any one individual (at least not to the best of my knowledge). I have a good friend who had to stop taking IGF1 due to stomach illness that was completely unrelated But he to experienced good gains from it for the 2 weeks he was on it, his dosage was 120mcg per day. One hour after the first injection he went to the gym and immediately told me about the uncontrollable pump he got from just one set.

That would indicate to me that he was experiencing some form of cell volumization. The general consensus on IGF1 seems to be that its benefits are as fallow: Increased Pump Pumps are reported to be so severe that workouts are often cut short due to lack of ability to the muscle through the full range of motion…ouch Gains retention is increased if IGF is used in a cycle I am not sure why, but IGF1 seems to make gains on a cycle stick with virtually no post cycle loss. Every bodybuilder I’ve spoken with seems to think this for some reason. Most of them use drugs like Anadrol or Dianabol with it because of the amount of size attained with these drugs. The usual draw back to these drugs is that in most users there is a post cycle “crash” that occurs, so the reasoning is to toss IGF1 into the stack and grow larger faster with out the post cycle crash blues.

Reverses testicular atrophy

Testicles if shrunken will return to “full swing” so to speak even in the middle of a cycle. If not shrunken they will not shrink during the cycle. This may explain partially why gains are kept after the cycle.

Fatigue

Users report feeling drained and tired all day. This seems to be one of the negative side effects to IGF1, it will make you sleep longer and you will require more sleep at night to feel rested for the morning. This is common with high doses of HGH and exhibited in children, whose IGF1 levels are extraordinarily high. A child needs 4 hours more sleep than an adult on average does. This may be directly or indirectly related to IGF1 levels.

(Video) GROWTH FACTOR DIFFERENCES!

Stiffness

An almost arthritic feeling is commonly associated with high levels of HGH, well IGF1 has the exact same property. IGF1 will cause your hands, fingers and knuckles to ache this is one way you can be sure you got real IGF1.

IGF-1’s Side effects

Every thing has a down side. To bake a cake ya gotta brake an egg. IGF1 is no exception. The drug used in larger quantity around the 100mcg+ range will cause headaches, occasional nausea and can contribute to low blood sugar orhypoglycemia in some users. Although I have never heard of this first hand I’m sure its true. IGF1 will attach its self to the lining of the intestine and cause atrophy of the gut. Every thing IGF1 touches will grow and you have a lot of receptors on the lining of the large intestine and inner wall of the abdominal well. This is what causes the GH gut look. You can easily avoid this by limiting your dosages and cycle lengths. IGF1 cycles should be kept to 4-6 weeks with 4-6 weeks off in-between. IGF-1 is considerably more powerful than HGH and you need to think of it along those lines as far as dosing goes. We all know what to much HGH can do over prolonged periods of usage. The Neanderthal look is definitely not going to win any shows this year. I would recommend 80 mcg a day for 4 weeks at a time you should get good results from that for a while. I don’t know if you will need to up the dosage at any point, but I would think in the case of IGF1 it wouldn’t matter. If 80mcg doesn’t do it for ya, then bump it up to 100 You should definitely feel it at this point If not suspect the IGF1 as being fake. Beyond 120 mcg per day your asking for trouble, Thiscompound demands as much respect as its sister amino Insulin.

Clinical Facts about IGF-1

IGF-1 is a polypeptide of 70 amino acids (7650 daltons), and is one of a number of related insulin-like growth factors present in the circulation. The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. IGF-1 is a mediator of longitudinal growth in humans or how tall you are capable of becoming. Serum IGF-1 concentrations are altered by age, nutritional status, body composition, and growth hormone secretion. A single basal IGF-1 level is useful in the assessment of short stature in children and in nutritional support studies of acutely ill patients. For the diagnosis of acromegaly, a single IGF-1 concentration is more reliable than a random hGH measurement (Oppizi, et al., 1986). IGF-1 can be used for the assessment of disease activity in acromegaly (Barkan, et al., 198.

Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins (IGFBPs), of which six classes (IGFBPs 1-6) have been identified (Rudd, 1991). BP3 is thought to be the major binding protein.

FAQs

What is IGF-1 LR3 used for? ›

IGF1-LR3 Peptide Therapy

IGF-1 LR3 inhibits the movement of glucose into the body's cells which facilitates fat burning and the use of fat in the body for the production of energy. Its effects last most of the day and have made it a preferred variant by a majority of patients and physicians.

Does IGF-1 LR3 really work? ›

There is little doubt that IGF 1 LR3 is effective at improving lean muscle and muscle mass. Notwithstanding, make sure you exercise caution with use considering the potency. IGF 1 LR3 is 3x more potent than its standard form so most keep cycles to under 30 days.

Does IGF-1 make you bigger? ›

Jokes aside, both IGF-1 and HGH cause various body tissues to grow bigger, muscle being the most important one. IGF-1 increases lean body mass,1 helping you burn fat, and builds up physical endurance. It increases protein synthesis, which in turn prompts tissue repair and accelerates recovery from injuries.

What does IGF-1 peptide do? ›

Insulin-like Growth Factor-1 (IGF-1) is a potent peptide factor involved in a broad range of tissue processes including cell growth and survival, proliferation, differentiation and metabolism, but the molecular basis of these diverse functions is not well understood.

Does IGF-1 have side effects? ›

The side effects of IGF-1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop.

Does IGF-1 cause weight gain? ›

Generally, you will accomplish much more in terms of muscle density and size at a normal genetic level. In other words, the weight gain that you will experience from the use of IGF-1 is not due to retention of water. The weight gain is caused by actual muscle growth and is a long term effect.

Does IGF-1 LR3 build muscle? ›

IGF-1 LR3 obstructs the movement of glucose into the body's cells. This facilitates fat burning and the use of fat in the body for the production of energy. IGF-1 LR3 has a life in the body for about 20-30 hours and therefore enhance the growth amount of muscle for a whole day.

Will IGF-1 make you fail a drug test? ›

IGF-1 is considered a performance-enhancer because it mediates human growth hormone levels in the body, but is not detectable by a urine test.

Why do bodybuilders use IGF? ›

IGF-I is typically used to enhance the anabolic effects of concurrent GH and/or anabolic steroid use.

Is IGF-1 safe to use? ›

The World Anti-Doping Agency (WADA) has banned all forms of IGF, including supplements. It says prescription IGF can permanently damage your joints, liver, and heart. OTC supplements aren't regulated, so there's no telling what's in them. Other people take IGF for anti-aging or overall health.

Does IGF-1 make you tired? ›

Higher plasma IGF-1 levels are associated with increased delta sleep in healthy older men.

Does IGF-1 cause aging? ›

The growth hormone/insulin-like growth factor 1 (GH/IGF1) signaling pathway, also referred to as the somatotropic axis, has been extensively implicated in the aging process (Bartke et al. 2003, Kenyon 2010, Barzilai et al.

Does IGF-1 make you lose weight? ›

Summary: Observational studies have linked low IGF-1 levels with high body mass index. Therefore, increasing IGF-1 levels could, theoretically, promote weight loss, but much more research is needed to support this.

Do bodybuilders take IGF-1? ›

IGF-1 is favored in the bodybuilding industry and for people who workout regularly. It helps enhance recovery time after workout and improves energy during the workout.

What does IGF-1 do in the brain? ›

IGF1 has been shown to have pleiotropic actions in all neural cells, including neurons, oligodendrocytes and astrocytes, by increasing cell number and promoting maturation and myelination.

Does IGF-1 cause erectile dysfunction? ›

In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.

Does IGF-1 Improve Skin? ›

IGF-1 has been shown to reduce wrinkles in the skin and therefore, is an effective cosmetic treatment agent [40, 41]. In human skin fibroblasts, the expression of IGFBP is regulated by factors, such as IGFs, TGF-β1, estradiol, and testosterone. ...

Does IGF-1 raise blood pressure? ›

Circulating IGF1 is known to induce vasodilation, which contributes to the regulation of arterial BP and vascular tone, while deletion of IGF1 in mice enhanced mechanisms of vasoconstriction leading to hypertension. Clinically, both a direct and inverse relation between IGF1 levels and BP has been reported.

Does IGF-1 make bones thicker? ›

Studies carried out in animal models have shown that IGF-1 can enhance longitudinal growth, periosteal circumference, and bone mineral density.

Can IGF-1 cause diabetes? ›

IGF1 is associated with metabolic parameters and involved in glucose metabolism. Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes.

What does IGF-1 do for men? ›

IGF-1 is a hormone that manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues. GH levels in the blood fluctuate throughout the day depending on your diet and activity levels.

How long can I run IGF lr3? ›

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day.

Should I take IGF-1 before or after workout? ›

This variant of IGF-1 should be taken daily for 7 days in a week. It's best to take it after a workout.

How long does it take to get IGF-1 results? ›

The IGF-1 Blood Test is also known as SM-C/IGF-1, Somatomedin-C, and Sulfation Factor. No fasting is required for this test, and results will be delivered within 1-2 days. For patients without insurance, this test is a convenient, low-cost alternative to a traditional doctor's office visit.

Is IGF-1 legal in the US? ›

IGF-1 is banned by both the FDA and the World Anti-Doping Agency, and is also a proven performance enhancer if taken in certain forms.

Is IGF-1 FDA approved? ›

IGF-1 is an FDA-approved (IND exemption #113450), commercially available compound that crosses the blood-brain barrier and has beneficial effects on synaptic development by promoting neuronal cell survival, synaptic maturation, and synaptic plasticity.

Are peptide injections safe? ›

GHS peptides may increase appetite and blood sugar levels or cause fluid retention. Their long-term safety is uncertain, and off-label use may not be safe.

Are peptides steroids? ›

Peptides and steroids are both similar yet polar opposites. The main difference, however, is that steroids increase testosterone levels unnaturally in the body whereas peptides simply increase the signal allowing the body to create more of this hormone naturally.

Do peptides really work? ›

Peptides are sold in dietary supplements including pills or protein shakes. They claim to help you build muscle, boost weight and fat loss, and help with muscle recovery. But there's little direct evidence to back up most of these statements. And it's not clear how well your body can absorb peptides from supplements.

Does caffeine increase IGF-1? ›

Coffee consumption can lower the insulin-like growth factor-1 (IGF-1) [5] which is associated with increased incidence of PC particularly high grade and advance stage disease [10, 27].

Does IGF increase appetite? ›

We found that IGF1 increased food intake while the anti-IGF1 antibody decreased appetite.

What happens if you have too much IGF-1? ›

But too much IGF-1 enlarges the face, feet and hands, as we see in acromegaly. It produces extreme height, especially during childhood and adolescence. It stimulates secretion of insulin while reducing that hormone's effectiveness , which can cause fatigue and intense hunger.

Which is better growth hormone or IGF-1? ›

HGH possesses some extra advantages (general rejuvenation of the body, the skin becomes smoother, the hair grows quicker, and a lot more) which are absent with IGF-1. IGF-1 has immediate effects, whereas HGH has a longer loading period. Taking both together is a popular supplement for bodybuilders.

What health problems are linked to high amounts of IGF-1? ›

IGF1 signaling plays a major role in controlling aging and lifespan. This factor is altered in obesity and many related diseases, including cardiovascular diseases and cancer.

What foods are high in IGF-1? ›

Which foods raise IGF-1? Since the primary dietary factor that determines IGF-1 levels is animal protein, the excessive meat, fowl, seafood, and dairy intake common in our society elevates circulating IGF-1. It is the amino acid distribution of animal protein that sparks IGF-1 production.

Can IGF-1 cause anxiety? ›

We found that serum IGF-I levels impact on anxiety responses and modulates brain expression of FKBP5 in mice, whereas in humans, lower levels of circulating IGF-I significantly correlated with higher occurrence of stressful events and lower FKBP5 expression.

Does IGF-1 increase inflammation? ›

Our data suggest that IGF1 excess induces pro-inflammatory cytokine production in circulating immune cells, and thereby potentiates the effect of endogenous TLR ligands. This effect is suggested to be mediated via the MAPK pathway and can possibly explain the increased cardiovascular risks in acromegaly.

Why do bodybuilders take IGF-1? ›

It's an anabolic hormone that stimulates the growth of bone, muscle and other tissues in the body. Due to its role in stimulating an increase in muscle volume and mass (a process known as hypertrophy), IGF-1 is important in building muscle and improving overall body composition.

Why do bodybuilders use IGF? ›

IGF-I is typically used to enhance the anabolic effects of concurrent GH and/or anabolic steroid use.

Does IGF-1 make bones thicker? ›

Studies carried out in animal models have shown that IGF-1 can enhance longitudinal growth, periosteal circumference, and bone mineral density.

What does IGF 3 do? ›

The pituitary gland regulates growth and the function of other glands. But IGFBP-3 is more than just a transporter. It also helps extend the life of somatomedin C in the blood and helps control its effects on body tissues. Levels of IGFBP-3 are highest during childhood and puberty, then they decrease during adulthood.

Does IGF-1 cause erectile dysfunction? ›

In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.

What does IGF-1 do for men? ›

IGF-1 is a hormone that manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues. GH levels in the blood fluctuate throughout the day depending on your diet and activity levels.

Is IGF-1 safe to use? ›

The World Anti-Doping Agency (WADA) has banned all forms of IGF, including supplements. It says prescription IGF can permanently damage your joints, liver, and heart. OTC supplements aren't regulated, so there's no telling what's in them. Other people take IGF for anti-aging or overall health.

Should I take IGF-1 before or after workout? ›

This variant of IGF-1 should be taken daily for 7 days in a week. It's best to take it after a workout.

What does IGF-1 do in the brain? ›

IGF1 has been shown to have pleiotropic actions in all neural cells, including neurons, oligodendrocytes and astrocytes, by increasing cell number and promoting maturation and myelination.

When should I take IGF LR3? ›

It is recommended to administer IGF-1 LR3 once daily for six weeks. After six weeks, take approximately 20-40 days off before starting a new course IGF-1 LR3. Consume protein with a combination of carbohydrates 15-20 minutes before administering IGF-1/ LR3 for best results.

Does IGF-1 increase aging? ›

The insulin-like growth factor 1 (IGF1) signaling pathway has emerged as a major regulator of the aging process, from rodents to humans. However, given the pleiotropic actions of IGF1, its role in the aging brain remains complex and controversial.

Can IGF-1 cause diabetes? ›

IGF1 is associated with metabolic parameters and involved in glucose metabolism. Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes.

What happens if you have too much IGF-1? ›

But too much IGF-1 enlarges the face, feet and hands, as we see in acromegaly. It produces extreme height, especially during childhood and adolescence. It stimulates secretion of insulin while reducing that hormone's effectiveness , which can cause fatigue and intense hunger.

Does IGF help with weight loss? ›

Summary: Observational studies have linked low IGF-1 levels with high body mass index. Therefore, increasing IGF-1 levels could, theoretically, promote weight loss, but much more research is needed to support this.

Does IGF increase appetite? ›

We found that IGF1 increased food intake while the anti-IGF1 antibody decreased appetite.

What foods are high in IGF-1? ›

Which foods raise IGF-1? Since the primary dietary factor that determines IGF-1 levels is animal protein, the excessive meat, fowl, seafood, and dairy intake common in our society elevates circulating IGF-1. It is the amino acid distribution of animal protein that sparks IGF-1 production.

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Author: Margart Wisoky

Last Updated: 12/06/2022

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Name: Margart Wisoky

Birthday: 1993-05-13

Address: 2113 Abernathy Knoll, New Tamerafurt, CT 66893-2169

Phone: +25815234346805

Job: Central Developer

Hobby: Machining, Pottery, Rafting, Cosplaying, Jogging, Taekwondo, Scouting

Introduction: My name is Margart Wisoky, I am a gorgeous, shiny, successful, beautiful, adventurous, excited, pleasant person who loves writing and wants to share my knowledge and understanding with you.